Picture of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Dr. Philip Griebel

Dr. Philip Griebel Professor and Canada Research Chair in Neonatal Mucosal Immunology

Research Areas

  • Developmental immunology
  • Comparative immunology
  • Mucosal immunology
  • Innate immunity
  • Vaccine delivery

Current Research

  • Identify key genes regulating innate mucosal immune responses
  • Analyze the interaction between Mycobacterium avium subspecies paratuberculosis and the mucosal immune system.
  • Investigate the role of neutrophils in antigen presentation and dendritic cell maturation
  • Develop a vaccine to prevent TSE disease
  • Identify biomarkers of stress responses and mechanisms by which stress alters immune responses

Current Courses

  • PUBH 806.3, Public Health Biology
  • VACC 801.3, Vaccines and Immunotherapeutics
  • VACC 802.3 Mucosal Immunology
  • VTINT 580.3, Strategic Vaccination
  • VTMC 832.3, Infectious Disease Epidemiology

Recent Grants and Awards

As Principal Investigator: 

Griebel, P. (PI) (2019-2024). NSERC- Development of gut and respiratory microbiome. $200,000 (CAD). to Griebel, Philip.

Griebel, P. (PI) (2017 - 2019). Study Agreement - Development of a respiratory bovine coronavirus model. $122500 (CAD). Merck Animal Health. $122500 (CAD) to Griebel, Philip.

Griebel, P. (PI) (2016 - 2019)- ADF - Control of Viral and Bacterial respiratory pathogens in Weaned Calves $246000 (CAD). Agriculture Development Fund, Ministry of Agriculture. $246000 (CAD) to Griebel, Philip.

Griebel, P. (PI) (2018 - 2021)- ADF – Development of Pink-eye Vaccine $210000 (CAD). Agriculture Development Fund, Ministry of Agriculture. $210000 (CAD) to Griebel, Philip.

As Co-Investigator: 

Potter, A. (PI) & Gerdts, V., Napper, S., Griebel, P., Townsend, H. (2015 - 2019). Reverse Vaccinology Approach for the Prevention of Mycobacterial Disease in Cattle, $1097710 (CAD). Large-Scale Applied Research Project Competition, Genome Prairie.

Napper, S. (PI) & Potter, A., Tikoo, S., Griebel, P. (2014 - 2017). Development of an Oral Vaccine for Chronic Wasting Disease, $206580 (CAD). Agriculture Development Fund, Ministry of Agriculture.

Recent Publications

Malmuthuge N, Guanxiang L, Griebel PJ, Guan, LL. (2019). Assessment of gut microbiome and host transcriptome in neonatal calves reveals a framework for understanding early life gut health. Appl Environ Microbiol AEM.02534-18. doi: 10.1128/AEM.02534-18.

Jimbo S, Griebel PJ, Lai K, Babiuk LA, Mutwiri G. (2019). Natural and inducible Bregs are widely distributed in ovine lymphoid tissues. Vet Immunol Immunopath 211; 44-48.

Malmuthuge N, Griebel PJ. (2019) A novel animal model for regional microbial dysbiosis of the pioneer microbial community. Frontiers Microbiology doi: 10.3389/fmicb.2019.01706

Dadarwal D, Gonzalez-Cano P, Dickinson R, Griebel P, Palmer C. (2019). Characterization of endometrial cytokine gene expression in normal versus endometritic postpartum dairy cows. Theriogenology 126, 128-139

Osman R, Malmuthuge N, Gonzalez-Cano P, Griebel PJ. (2018). Development and Function of the Mucosal Immune System in the Upper Respiratory Tract of Neonatal Calves. Annual Review of Animal Bioscience 6: 141-55.

Priyadarshini S, Pradhan B, Griebel P, Aich P. (2018) Cortisol regulates immune and metabolic processes in murine adipocytes and macrophages through HTR2a and HTR5c serotonin receptors, Eur J Cell Biol 97(7); 483-92

Malmuthuge N, Griebel PJ. (2018). Fetal environment and fetal intestine are sterile during the third trimester of pregnancy. Vet Immunol Immunopath 204: 59-64.

Wood ME, Griebel P, Huizenga M, Lockwood S, Hansen C, Potter A, Cashman N, Mapletoft JW, Napper S.  (2018). Accelerated onset of chronic wasting disease in Rocky Mountain elk (Cervus canadensis) vaccinated with a PrPSc-specific vaccine and housed in a prion contaminated environment. Vaccine 36(50), 7737-7743

Taschuk R, Scruten E, Woodbury M, Cashman N, Potter A, Griebel P, Tikoo SK, Napper S. (2017). Induction of PrPSc-Specific Systemic and Mucosal Immune Responses in White-tailed Deer with an Oral Vaccine for Chronic Wasting Diseas. Prion 11(5):368-380.

Osman RA, Griebel PJ. (2017). CD335 NKp46+ T cell recruitment to the bovine upper respiratory tract during a primary BHV-1 infection. Frontiers Immunology doi.org/10.3389/ fimmu.2017.01393