Picture of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Dr. Philip Griebel

Dr. Philip Griebel Professor and Canada Research Chair in Neonatal Mucosal Immunology

Research areas

  • Developmental immunology
  • Comparative immunology
  • Mucosal immunology
  • Innate immunity
  • Vaccine delivery

Current research

  • Identify key genes regulating innate mucosal immune responses
  • Analyze the interaction between Mycobacterium avium subspecies paratuberculosis and the mucosal immune system.
  • Investigate the role of neutrophils in antigen presentation and dendritic cell maturation
  • Develop a vaccine to prevent TSE disease
  • Identify biomarkers of stress responses and mechanisms by which stress alters immune responses

Current courses

  • PUBH 898 Development and Function of the Mucosal Immune System: Challenges and Opportunities

Recent grants and awards

NSERC. Linking Innate and Adaptive Immunity: The Role of Neutrophils. (PI) (2008-2013)

CIHR Tier I CRC Mucosal Immunology of the neonate. (PI) (2009-2016)

Select publications

Taschuk R, Van der Merwe J, Marciniuk K, Potter A, Cashman N, Griebel P, Napper S. 2015.  In VitroNeutralization of Prions with PrPSc-Specific Antibodies.  Prion 9(4):292-303.

Malmuthuge N, Griebel PJ, Guan LL. 2015. Role of the microbiome in the development and function of the gastrointestinal tract of newborn calves. Frontiers in Veterinary Science 23

Ahmed KA, Wang L, Mousseau D, Griebel, PJ, Xiang J. 2015. mTOR signal threshold switches T-cell fate by kinesin motor KIF13A. Journal of Leukocyte Biology 98(3):313-8.

Griebel, PJ. 2015. BVDV Vaccination in North America: Risks Versus Benefits. Animal Health Research Reviews 16(1): 27-32.

Liang G, Malmuthuge N, Guan LL, Griebel PJ. 2015. Model Systems to Analyze the Role of miRNAs and Commensal Microflora in Bovine Mucosal Immune System Development. Molecular Immunology 66:57-66.

Zhou M Chen Y, Griebel PJ, Guan LL. 2014. Methanogen Prevalence throughout the Gastrointestinal Tract of Pre-Weaned Dairy Calves. Gut Microbes 5(5):628-38. 

Griebel PJ, Hill K, Stookey J. 2014. How Stress Alters Immune Responses During Respiratory Infection. Animal Health Research Reviews 15(2): 161-165.

Mirabzadeh-Ardakani A, Griebel P, Schmutz SM. 2014. Identification of a non-coding exon in the bovine DEFB103 gene. Gene 551,183-188.

Arsenault RJ, Maattanen P, Daigle J, Potter A, Griebel P, Napper S. From Mouth to Macrophage: Mechanisms of Innate Immune Subversion by Mycobacterium avium subsp. paratuberculosis. Frontiers Veterinary Research 45:54

Robertson AJ, Trost B,  Scruten E, Robertson T, Mostajeran M, Conner W, Kusalik A, Griebel P, Napper S. 2014. Identification of Developmentally-Specific Kinotypes and Mechanisms of Varroa Mite Resistance through Whole Organism Kinome Analysis. Frontiers Genetics May 21;5:139. doi: 10.3389