- Vaccines, adjuvants and immunotherapeutic agents
- Vaccine formulation and delivery systems
- Immunobiology of Toll-like receptors
- Mucosal immunology
- research and development of vaccines and immunotherapeutic agents
- the discovery and development of novel vaccine adjuvants, and investigating their mechanisms of actions
- exploring various approaches to improve the efficacy of vaccines and immunotherapeutic agents through appropriate formulation and delivery
- investigating how innate immune responses are regulated in the intestines, using TLR9 activation as a model
- PUBH 806.3 Public Health Biology
- VACC 801.3 Vaccinology & Immunotherapeutics
Recent Grants and Awards
As Principal Investigator:
2019-2024 - NSERC Discovery, Mechanisms of action of adjuvants in pigs ($165,000)
2016-2019 - Agricultural Development Fund – Saskatchewan, Development of an Influenza vaccine ($185,000)
2014-2019 - NSERC Discovery, Innate immune responses in pigs ($150,000)
2012-2015 - Alberta Livestock and Meat (ALMA), Improving swine influenza vaccines with new generation adjuvants ($160,800)
2017-2022 - Tait, C (PI), Mutwiri, G, et al., CIHR, Building Reconciliation Together: Transformative Intergenerational Mentorship. Training Grant – Indigenous mentorship Network Program. ($1,000,000)
2017-2018 - Crizzle, A (PI), Mutwiri, G., et al., CIHR, Developing Priorities and Research Initiatives to address HIV among Indigenous Communities in Saskatchewan ($14,282)
2016 - Tait, C (PI), Mutwiri, G, et al., CIHR, Indigenous Mentorship Program Network – LOI, Training Grant ($25,000)
B. Magiri, Y. Huang, K. Lai, H. Wilson and G. Mutwiri. (2019). Innate immune response profiles in pigs injected with vaccines adjuvants polydi(sodium carboxylatoethylphenoxy)phosphazene (PCEP) and emulsigen. Veterinary Immunology & Immunopathology. 209: 7-16.
B. Magiri, G. Mutwiri and H.L. Wilson. (2018). Recent advances in experimental polyphosphazene adjuvants and their mechanisms of action. Cell and Tissue Research. 374: 465-71.
B. Magiri, K. Lai, A.M. Chaffey, Y. Zhou, H.M. Pyo, V. Gerdts, H.L. Wilson, and G. Mutwiri. (2018). Intradermal immunization with inactivated swine influenza virus and adjuvant polydi(sodium carboxylatoethylphenoxy)phosphazene (PCEP) induced humoral and cell-mediated immunity and reduced lung viral titres in pigs. Vaccine. 36: 1606-13.
J.B. Darbellay, B. Cox, K. Lai, M. Delgado-Ortega, C. Wheler, D. Wilson, S. Walker, G. Starrak, H. Duncan, Y. Huang, G. Mutwiri, A. Potter, M. Gilmour, D. Safronetz, V. Gerdts, and U. Karniychuk. 2017. Zika Virus causes persistent infection in porcine conceptuses and may impair health in offspring. EBioMedicine. 25: 73-86.
B. Magiri, K. Lai, A.M. Chaffey, H.L. Wilson, W.E. Berry, M.L. Szafron and G. Mutwiri. (2016). Response of Immune response genes to adjuvants poly[di(sodium carboxylatoethylphenoxy)phosphazene](PCEP), CpG oligodeoxynucleotide and emulsigen at intradermal injection site in pigs. Veterinary Immunology and Immunopathology. 175: 57-63.
S. Jimbo, P.J. Griebel, H. Townsend, L.A. Babiuk and G. Mutwiri. (2016). Evidence for the existence of regulatory and effector B cell populations in Peyer’s patches of sheep. Veterinary Immunology and Immunopathology. 174: 26-34.
S. Backes, C. Jager, C.J. Dembek, A.D. Kosinka, T. Bauer, A.S. Stephan, A. Dislers, G. Mutwiri, D.H. Busch, L.A. Babiuk, G. Gasteiger and U. Protzer. (2016). Protein-prime/modified vaccinia Ankara vector-boost vaccination overcomes tolerance in high-antigenic HBV-transgenic mice. Vaccine. 34: 923-32.
J.A. Pasternak, S.H. Ng, R.M. Buchanan, S. Mertins, G. Mutwiri, V. Gerdts and H.L. Wislon. (2015). Oral antigen exposure in newborn piglets circumvents induction of oral tolerance in response to intraperitoenal vaccination in later life. BMC Veterinary Research. 11: 50.
S. Awate, F.N. Eng, V. Gerdts, L.A. Babiuk and G. Mutwiri. (2014). Caspase-1 dependent IL-1b secretion and antigen-specific T-cell activation by the novel adjuvant PCEP. Vaccines (Basel). 2: 500-14.